The Institute of Immunology (ÚI) was established in 1995. It was created from the merger of the Department of Clinical Immunology at the Motol Teaching Hospital and the Institute of Immunology of the Second Medical Faculty into a single institution active in health care and teaching. Since 1995, the Institute of Immunology underwent many changes in terms of the organization of its activities, a significant expansion of its health care and teaching components and an intensifying of its research activities. The Institute is awarded research grants from the Ministries of Education a Health and International EU grants. Employees of the institute published many original articles in renowned journals and are authors of textbooks and monographs. At present, the Institute is one of the most significant immunology workplaces in the Czech Republic; it plays an important role through the cooperation with other departments of the Motol Teaching Hospital in the diagnosis and treatment of primary immunodeficiencies, autoimmune disorders and leukemia primarily in children. Successful developments in the field of cancer immunology based on the research into tumour vaccines on the basis of dendritic cells. In 2003, the Institute was recognized as a workplace fulfilling the requirements of the American Federation of Societies for Clinical Immunology (FOCIS) and became part of the international chain of Centers for Clinical Immunology.