COVID-19

During the ongoing COVID pandemic, the Department of Immunology became a center for collecting clinical and research data of patients hospitalized at the University Hospital Motol.
These prospective studies resulted in a publication summarizing the characteristics of patient cohorts by disease severity and prognosis. Researchers at the Institute of Immunology also followed up by studying the immune mechanisms accompanying the disease, with special emphasis on the role of innate immunity, especially neutrophils.
The activity is reflected in publications on the topic, which contribute to the worldwide rise of scientific activities during the COVID-19 pandemic.

People

 

 

Publications

Strizova Z, Smetanova J, Bartunkova J, Milota T. Principles and Challenges in anti-COVID-19 Vaccine Development. Int Arch Allergy Immunol. 2021;182(4):339-349. doi: 10.1159/000514225. Epub 2021 Feb 1. PMID: 33524979; PMCID: PMC7900461.

Smetanová J, Střížová Z, Bartůňková J, Milota T. Principles and new perspectives in the vaccination against SARS-CoV-2 virus. Cas Lek Cesk. 2020 Winter;159(7-8):298-302. English. PMID: 33445936.

Paces J, Strizova Z, Smrz D, Cerny J. COVID-19 and the immune system. Physiol Res. 2020 Jul 16;69(3):379-388. doi: 10.33549/physiolres.934492. Epub 2020 May 29. PMID: 32469225.

Searching for COVID-19 Antibodies in Czech Children—A Needle in the Haystack
Front. Pediatr., 12 November 2020

Can wearing face masks in public affect transmission route and viral load in COVID-19?
Cent Eur J Public Health. 2020 Jun;28(2):161-162. doi: 10.21101/cejph.a6290.

Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils' but Impaired Monocytes' and Dendritic Cells' Responsiveness
Cells  2020 Sep 29;9(10):2206. doi: 10.3390/cells9102206.

Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19
J Clin Med. 2020 Sep 17;9(9):3000. doi: 10.3390/jcm9093000.

Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19
Front Immunol. 2020 Jul 3;11:1665. doi: 10.3389/fimmu.2020.01665.

Created: 23. 11. 2020 / Modified: 6. 5. 2021 / Responsible person: RNDr. Jan Lašťovička, CSc.